Toxicity assessment and modeling of Moringa oleifera seeds in water purification by whole cell bioreporter

Al-Anizi, Ali Adnan and Hellyer, Maria Theresa and Zhang, Dayi (2014) Toxicity assessment and modeling of Moringa oleifera seeds in water purification by whole cell bioreporter. Water Research, 56. pp. 77-87. ISSN 0043-1354

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Abstract

Moringa oleifera has been used as a coagulation reagent for drinking water purification, especially in developing countries such as Malawi. This research revealed the cytoxicity and genotoxicity of M. oleifera by Acinetobacter bioreporter. The results indicated that significant cytoxicity effects were observed when the powdered M. oleifera seeds concentration is from 1 mg/L to 50 mg/L. Through direct contact, ethanolic-water extraction and hexane extraction, the toxic effects of hydrophobic and hydrophilic components in M. oleifera seeds were distinguished. It suggested that the hydrophobic lipids contributed to the dominant cytoxicity, consequently resulting in the dominant genotoxicity in the water-soluble fraction due to limited dissolution when the M. oleifera seeds granule concentration was from 10 to 1000 mg/L. Based on cytoxicity and genotoxicity model, the LC50 and LC90 of M. oleifera seeds were 8.5 mg/L and 300 mg/L respectively and their genotoxicity was equivalent to 8.3 mg mitomycin C per 1.0 g dry M. oleifera seed. The toxicity of M. oleifera has also remarkable synergistic effects, suggesting whole cell biosensor as an appropriate and complementary tool to chemical analysis for environmental toxicity assessment.

Item Type:
Journal Article
Journal or Publication Title:
Water Research
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2300/2311
Subjects:
?? MORINGA OLEIFERACYTOXICITY GENOTOXICITY WHOLE CELL BIOREPORTER ACINETOBACTER BAYLYI ADP1WATER SCIENCE AND TECHNOLOGYPOLLUTIONECOLOGICAL MODELLINGWASTE MANAGEMENT AND DISPOSAL ??
ID Code:
68904
Deposited By:
Deposited On:
18 Mar 2014 11:23
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Sep 2023 00:22