Trypanosomatid Phosphoproteomics

Urbaniak, Mick (2014) Trypanosomatid Phosphoproteomics. In: Protein phosphorylation in parasites. Drug Discovery in Infectious Diseases . Wiley Blackwell, Chichester, pp. 63-78. ISBN 9783527332359

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The reversible phosphorylation of serine, threonine and tyrosine plays an important role in the biology of trypanosomatids. The identification and quantification of phosphorylation site dynamics will not only assist the elucidation of signaling pathways at the molecular level, but will also facilitate drug discovery through improved candidate selection and mode-of-action studies. Recent advances in the field of mass spectrometry-based phosphoproteomics have made the experimental observation and quantitation of thousands of phosphorylation sites feasible outside of specialist mass spectrometry laboratories. In this chapter, an introduction to phosphoproteomic techniques is presented, the current state of knowledge of the trypanosomatid phosphoproteomes is reviewed, and the potential impact of quantitative phosphoproteomics is discussed.

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25 Feb 2014 09:53
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19 Sep 2023 03:22