Cell-nonautonomous effects of dFOXO/DAF-16 in aging

Alic, Nazif and Tullet, Jennifer M. and Niccoli, Teresa and Broughton, Susan and Hoddinott, Matthew P. and Slack, Cathy and Gems, David and Partridge, Linda (2014) Cell-nonautonomous effects of dFOXO/DAF-16 in aging. Cell Reports, 6 (4). pp. 608-616. ISSN 2211-1247

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Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively. Both are required for lifespan extension by reduced insulin/Igf signaling, and their activation in key tissues can extend lifespan. Aging of these tissues may limit lifespan. Alternatively, FoxOs may promote longevity cell nonautonomously by signaling to themselves (FoxO to FoxO) or other factors (FoxO to other) in distal tissues. Here, we show that activation of dFOXO and DAF-16 in the gut/fat body does not require dfoxo/daf-16 elsewhere to extend lifespan. Rather, in Drosophila, activation of dFOXO in the gut/fat body or in neuroendocrine cells acts on other organs to promote healthy aging by signaling to other, as-yet-unidentified factors. Whereas FoxO-to-FoxO signaling appears to be required for metabolic homeostasis, our results pinpoint FoxO-to-other signaling as an important mechanism through which localized FoxO activity ameliorates aging.

Item Type:
Journal Article
Journal or Publication Title:
Cell Reports
Additional Information:
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
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?? general biochemistry,genetics and molecular biologybiochemistry, genetics and molecular biology(all) ??
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Deposited On:
14 Feb 2014 09:10
Last Modified:
21 Jul 2024 00:29