Discrete conductance levels in calcium channel models:multiband calcium selective conduction

Eisenberg, Robert S. and Kaufman, Igor and Luchinsky, Dmitrii G. and Tindjong, Rodrigue and McClintock, Peter V. E. (2013) Discrete conductance levels in calcium channel models:multiband calcium selective conduction. Biophysical Journal, 104 (2, Sup). 358a. ISSN 0006-3495

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Abstract

Brownian dynamics were simulated for the simple model of calcium channels introduced by Nonner and Eisenberg, computing electric forces from all charges. Permanent charge (of acidic side chains) was varied. Substantial conduction was found only at certain discrete values of permanent charge. Different con-duction states had different selectivity, one resembling L-type CaV1 and the other RyR channels. We speculate that thermally acti-vated switching between conductance values could produce some types of spon-taneous gating. Below is calcium current J as a function of permanent charge Qf and calcium concentration.

Item Type:
Journal Article
Journal or Publication Title:
Biophysical Journal
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1304
Subjects:
ID Code:
67712
Deposited By:
Deposited On:
25 Nov 2013 11:34
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jul 2020 01:27