Rosen's (M,R) system in process algebra

Gatherer, Derek and Galpin, Vashti (2013) Rosen's (M,R) system in process algebra. BMC Systems Biology, 7 (1): 128. ISSN 1752-0509

[thumbnail of 1752-0509-7-128]
Preview
PDF (1752-0509-7-128)
1752_0509_7_128.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

Robert Rosen's Metabolism-Replacement, or (M,R), system can be represented as a compact network structure with a single source and three products derived from that source in three consecutive reactions. (M,R) has been claimed to be non-reducible to its components and algorithmically non-computable, in the sense of not being evaluable as a function by a Turing machine. If (M,R)-like structures are present in real biological networks, this suggests that many biological networks will be non-computable, with implications for those branches of systems biology that rely on in silico modelling for predictive purposes.

Item Type:
Journal Article
Journal or Publication Title:
BMC Systems Biology
Additional Information:
© 2013 Gatherer and Galpin; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1315
Subjects:
?? robert rosen(m,r) metabolism-replacement metabolism-repair relational biology process algebra bio-pepa computability turing machinestructural biologymodelling and simulationmolecular biologyapplied mathematics ??
ID Code:
67601
Deposited By:
Deposited On:
20 Nov 2013 09:31
Refereed?:
Yes
Published?:
Published
Last Modified:
07 Aug 2024 23:43