Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue

Wessels, Quenton and Pretorius, Etheresia (2015) Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue. International Wound Journal, 12 (4). pp. 428-431. ISSN 1742-481X

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Abstract

Burn wound care today has a primary objective of temporary or permanent wound closure. Commercially available engineered alternative tissues have become a valuable adjunct to the treatment of burn injuries. Their constituents can be biological, alloplastic or a combination of both. Here the authors describe the aspects of the development of a siloxane epidermis for a collagen-glycosaminoglycan and for nylon-based artificial skin replacement products. A method to fabricate an ultra-thin epidermal equivalent is described. Pores, to allow the escape of wound exudate, were punched and a tri-filament nylon mesh or collagen scaffold was imbedded and silicone polymerisation followed at 120°C for 5 minutes. The ultra-structure of these bilaminates was assessed through scanning electron microscopy. An ultra-thin biomedical grade siloxane film was reliably created through precision coating on a pre-treated polyethylene terephthalate carrier.

Item Type:
Journal Article
Journal or Publication Title:
International Wound Journal
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2708
Subjects:
ID Code:
67250
Deposited By:
Deposited On:
22 Oct 2013 07:51
Refereed?:
Yes
Published?:
Published
Last Modified:
11 Jun 2020 02:59