Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

Gault, V. A. and Porter, W. D. and Flatt, P. R. and Holscher, Christian (2010) Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. International Journal of Obesity, 34. pp. 1341-1344. ISSN 0307-0565

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Abstract

High-calorie diet has been shown to impair learning ability and hippocampal synaptic plasticity in rodents. This study examined effects of daily treatment with the glucagon-like peptide-1 mimetic, exendin-4, on cognitive function and hippocampal synaptic plasticity in a model of diet-induced obesity, which exhibits compromised cognitive performance. Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg−1 bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days. In addition to improving metabolic control, exendin-4-treated mice exhibited a marked increase in recognition index highlighting improved learning and memory. High-fat diet resulted in the elimination of in vivo electrophysiological long-term potentiation, which was rescued following exendin-4 treatment. This study shows that exendin-4 therapy improves cognitive function and ameliorates impaired hippocampal synaptic plasticity in dietary-induced obesity.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Obesity
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2900/2916
Subjects:
ID Code:
67235
Deposited By:
Deposited On:
21 Oct 2013 17:59
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jul 2020 01:25