The genome of Epstein-Barr virus type 2 strain AG876

Dolan, Aidan and Addison, Clare and Gatherer, Derek and Davison, Andrew J. and McGeoch, Duncan J. (2006) The genome of Epstein-Barr virus type 2 strain AG876. Virology, 350 (1). pp. 164-170. ISSN 0042-6822

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Abstract

Two Epstein-Barr virus (EBV) types are known, EBV1 and EBV2, which possess substantially diverged alleles for latency genes EBNA-2, EBNA-3A, EBNA-3B and EBNA-3C but are thought to be otherwise similar. We report the first complete EBV2 genome sequence, for strain AG876, as 172,764 bp. The sequence was interpreted as containing at least 80 protein coding genes. Comparison with the published EBV1 sequence demonstrated that the two sequences are collinear and, outside the known diverged alleles, generally very close. The EBNA-1 gene was identified as another diverged locus, although its variation is believed not to correlate with EBV type. Patterns of substitution between the two genomes presented a wide spectrum of classes of change. No evidence was seen for involvement of B-cell-specific hypermutation systems in generation of the diverged alleles. Overall, genomic comparisons indicated that the two EBV types should be regarded as belonging to the same virus species. (c) 2006 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Journal or Publication Title: Virology
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2400/2406
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 66875
Deposited By: ep_importer_pure
Deposited On: 30 Sep 2013 14:26
Refereed?: Yes
Published?: Published
Last Modified: 11 Feb 2020 08:15
URI: https://eprints.lancs.ac.uk/id/eprint/66875

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