Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation

Horst, Daniëlle and Burrows, Scott R. and Gatherer, Derek and van Wilgenburg, Bonnie and Boer, Ingrid G. J. and Bell, Melissa J. and Ressing, Maaike E. and Wiertz, Emmanuel J. H. J. (2012) Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation. Journal of Virology, 86 (1). pp. 572-577. ISSN 0022-538X

Full text not available from this repository.

Abstract

The Epstein-Barr virus (EBV)-encoded immune evasion protein BNLF2a inhibits the transporter associated with antigen processing (TAP), thereby downregulating HLA class I expression at the cell surface. As a consequence, recognition of EBV-infected cells by cytotoxic T cells is impaired. Here, we show that sequence polymorphism of the BNLF2a protein is observed with natural EBV isolates, with evidence for positive selection. Despite these mutations, the BNLF2a variants efficiently reduce cell surface HLA class I levels. This conservation of BNLF2a function during evolution of EBV implies an important role for the viral TAP inhibitor in preventing T cell recognition during viral infection.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Virology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400/2406
Subjects:
ID Code:
66856
Deposited By:
Deposited On:
30 Sep 2013 07:50
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 08:39