Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression

Dawson, Neil and Ferrington, Linda and Lesch, Klaus-Peter and Kelly, Paul (2011) Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European Neuropsychopharmacology, 21 (1). pp. 117-128. ISSN 1873-7862

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Abstract

Variation in the human serotonin transporter gene (hSERT; 5-HTT) resulting in a life-long alteration in SERT function influences anxiety and the risk of developing affective disorders. The mechanisms underlying the influence of the hSERT gene on these phenotypes remain unclear but may involve altered 5-HT receptor function. Here we characterise the cerebral metabolic response to 5-HT2A/C receptor activation in two transgenic mouse models of altered SERT function, SERT knock-out (SERT KO) and hSERT over-expressing (hSERT OE) mice, to test the hypothesis that genetically mediated variability in SERT expression alters 5-HT2A/C function. We found that a constitutive increase in SERT expression (hSERT OE) enhanced, whereas a constitutive decrease in SERT expression (SERT KO) attenuated, 5-HT2A/C function. Therefore, altered 5-HT2A/C receptor functioning in response to hSERT gene variation may contribute to its influence on affective phenotypes

Item Type:
Journal Article
Journal or Publication Title:
European Neuropsychopharmacology
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2808
Subjects:
ID Code:
66816
Deposited By:
Deposited On:
26 Sep 2013 15:09
Refereed?:
Yes
Published?:
Published
Last Modified:
03 Mar 2020 08:31