A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson’s disease

Foulds, Penny and Diggle, Peter and Mitchell, John Douglas and Parker, Angela and Hasegawa, Masato and Masuda-Suzukake, Masami and Mann, David M. A. and Allsop, David (2013) A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson’s disease. Scientific Reports, 3.

Full text not available from this repository.

Abstract

There have been no longitudinal studies on α-synuclein as a potential biomarker for the progression of Parkinson’s disease (PD). Here, blood plasma ‘total α-synuclein’ and ‘Ser-129 phosphorylated α-synuclein’ were assayed at 4–6 monthly intervals from a cohort of 189 newly-diagnosed patients with PD. For log-transformed data, plasma total α-synuclein levels increased with time for up to 20 yrs after the appearance of initial symptoms (p = 0.012), whereas phosphorylated α-synuclein remained constant over this same period. The mean level of phosphorylated α-synuclein, but not of total α-synuclein, was higher in the PD plasma samples taken at first visit than in single samples taken from a group of 91 healthy controls (p = 0.012). Overall, we conclude that the plasma level of phosphorylated α-synuclein has potential value as a diagnostic tool, whereas the level of total α-synuclein could act as a surrogate marker for the progression of PD.

Item Type:
Journal Article
Journal or Publication Title:
Scientific Reports
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1000
Subjects:
ID Code:
66716
Deposited By:
Deposited On:
23 Sep 2013 15:11
Refereed?:
Yes
Published?:
Published
Last Modified:
24 Sep 2020 07:14