Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

Urbaniak, Michael D. and Frost, Lisa M. and Bingham, John P. and Kelland, Lloyd R. and Hartley, John A. and Woolfson, Derek N. and Caddick, Stephen (2003) Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore. Bioorganic and Medicinal Chemistry Letters, 13 (12). pp. 2025-2027. ISSN 0960-894X

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Abstract

Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.

Item Type:
Journal Article
Journal or Publication Title:
Bioorganic and Medicinal Chemistry Letters
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1308
Subjects:
ID Code:
66401
Deposited By:
Deposited On:
17 Sep 2013 08:08
Refereed?:
Yes
Published?:
Published
Last Modified:
07 Jul 2020 03:07