A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

Wolfsegger, Martin J. and Gutjahr, Georg and Engl, Werner and Jaki, Thomas (2014) A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships. Biometrics, 70 (1). pp. 103-109. ISSN 0006-341X

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Abstract

This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose–response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.

Item Type:
Journal Article
Journal or Publication Title:
Biometrics
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
66247
Deposited By:
Deposited On:
17 Sep 2013 08:03
Refereed?:
Yes
Published?:
Published
Last Modified:
24 Mar 2020 03:32