What does validation of cases in electronic record databases mean?:The potential contribution of free text

Nicholson, Amanda and Tate, Anne Rosemary and Koeling, Rob and Cassell, Jackie A (2011) What does validation of cases in electronic record databases mean?:The potential contribution of free text. Pharmacoepidemiology and Drug Safety, 20 (3). pp. 321-4. ISSN 1099-1557

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Abstract

Electronic health records are increasingly used for research. The definition of cases or endpoints often relies on the use of coded diagnostic data, using a pre-selected group of codes. Validation of these cases, as 'true' cases of the disease, is crucial. There are, however, ambiguities in what is meant by validation in the context of electronic records. Validation usually implies comparison of a definition against a gold standard of diagnosis and the ability to identify false negatives ('true' cases which were not detected) as well as false positives (detected cases which did not have the condition). We argue that two separate concepts of validation are often conflated in existing studies. Firstly, whether the GP thought the patient was suffering from a particular condition (which we term confirmation or internal validation) and secondly, whether the patient really had the condition (external validation). Few studies have the ability to detect false negatives who have not received a diagnostic code. Natural language processing is likely to open up the use of free text within the electronic record which will facilitate both the validation of the coded diagnosis and searching for false negatives.

Item Type:
Journal Article
Journal or Publication Title:
Pharmacoepidemiology and Drug Safety
Additional Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2736
Subjects:
ID Code:
66211
Deposited By:
Deposited On:
17 Sep 2013 08:03
Refereed?:
Yes
Published?:
Published
Last Modified:
12 Aug 2020 03:06