Triply interlocked covalent organic cages

Hasell, Tom and Wu, Xiaofeng and Jones, James T. A. and Bacsa, John and Steiner, Alexander and Mitra, Tamoghna and Trewin, Abbie and Adams, Dave J. and Cooper, Andrew I. (2010) Triply interlocked covalent organic cages. Nature Chemistry, 2 (9). pp. 750-755. ISSN 1755-4330

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Interlocked molecules comprise two or more separate components that are joined by 'mechanical' rather than covalent bonds. In other words, these molecular assemblies cannot be dissociated without the cleavage of one or more chemical bonds. Although recent progress has enabled the preparation of such topologies through coordination or templating interactions, three-dimensional interlocked covalent architectures remain difficult to prepare. Here, we present a template-free one-pot synthesis of triply interlocked organic cages. These 20-component dimers consist of two tetrahedral monomeric cages each built from four nodes and six linkers. The monomers exhibit axial chirality, which is recognized by their partner cage during the template-free interlocking assembly process. The dimeric cages also include two well-defined cavities per assembly, which for one of the systems studied led to the formation of a supramolecular host-guest chain. These interlocked organic molecules may prove useful as part of a toolkit for the modular construction of complex porous solids and other supramolecular assemblies.

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Journal Article
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Nature Chemistry
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12 Aug 2013 10:57
Last Modified:
18 Sep 2023 00:43