Alders, Mariëlle and Hodges, Matt and Hadjantonakis, Anna-Katerina and Postmus, Jan and van Wijk, Inge and Bliek, Jet and de Meulemeester, Maurice and Westerveld, Andries and Guillemot, François and Oudejans, Cees and Little, Peter and Mannens, Marcel (1997) The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts. Human Molecular Genetics, 6 (6). pp. 859-867. ISSN 1460-2083
Full text not available from this repository.Abstract
Here we describe the cloning of the human Achaete Scute Homologue 2 (HASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2), a homologue of the DrosophilaAchaete and Scute genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man. HASH2 is expressed in the extravillus trophoblasts of the developing placenta only. The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH2 is also imprinted in man.