Flies, worms and the Free Radical Theory of ageing

Clancy, David and Birdsall, John (2013) Flies, worms and the Free Radical Theory of ageing. Ageing Research Reviews, 12 (1). pp. 404-412. ISSN 1872-9649

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Abstract

Drosophila and Caenorhabditis elegans have provided the largest body of evidence addressing the Free Radical Theory of ageing, however the evidence has not been unequivocally supportive. Oxidative damage to DNA is probably not a major contributor, damage to lipids is assuming greater importance and damage to proteins probably the source of pathology. On balance the evidence does not support a primary role of oxidative damage in ageing in C. elegans, perhaps because of its particular energy metabolic and stress resistance profile. Evidence is more numerous, varied and consistent and hence more compelling for Drosophila, although not conclusive. However there is good evidence for a role of oxidative damage in later life pathology. Future work should: 1/ make more use of protein oxidative damage measurements; 2/ use inducible transgenic systems or pharmacotherapy to ensure genetic equivalence of controls and avoid confounding effects during development; 3/ to try to delay ageing, target interventions which reduce and/or repair protein oxidative damage.

Item Type:
Journal Article
Journal or Publication Title:
Ageing Research Reviews
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2808
Subjects:
ID Code:
65261
Deposited By:
Deposited On:
18 Jun 2013 08:43
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Apr 2020 02:47