Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes

Kambris, Zakaria and Cook, Peter E. and Phuc, Hoang K. and Sinkins, Steven P. (2009) Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science, 326 (5949). pp. 134-136. ISSN 0036-8075

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Abstract

Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito’s innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.

Item Type: Journal Article
Journal or Publication Title: Science
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1000
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 64947
Deposited By: ep_importer_pure
Deposited On: 12 Jun 2013 03:52
Refereed?: Yes
Published?: Published
Last Modified: 15 Feb 2020 03:38
URI: https://eprints.lancs.ac.uk/id/eprint/64947

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