Simultaneous confidence intervals that are compatible with closed testing in adaptive designs

Magirr, Dominic and Jaki, Thomas and Posch, Martin and Klingelmueller, Florian (2013) Simultaneous confidence intervals that are compatible with closed testing in adaptive designs. Biometrika, 100 (4). pp. 985-996. ISSN 0006-3444

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Abstract

We describe a general method for finding a confidence region for a parameter vector that is compatible with the decisions of a two-stage closed test procedure in an adaptive experiment. The closed test procedure is characterized by the fact that rejection or nonrejection of a null hypothesis may depend on the decisions for other hypotheses and the compatible confidence region will, in general, have a complex, nonrectangular shape. We find the smallest cross-product of simultaneous confidence intervals containing the region and provide computational shortcuts for calculating the lower bounds on parameters corresponding to the rejected null hypotheses. We illustrate the method with an adaptive phase II/III clinical trial.

Item Type:
Journal Article
Journal or Publication Title:
Biometrika
Additional Information:
C 2013 Biometrika Trust. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1100/1101
Subjects:
ID Code:
64480
Deposited By:
Deposited On:
13 May 2013 13:27
Refereed?:
Yes
Published?:
Published
Last Modified:
30 Sep 2020 00:38