How does symmetry impact the flexibility of proteins?

Schulze, Bernd and Sljoka, Adnan and Whiteley, Walter (2014) How does symmetry impact the flexibility of proteins? Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences, 372 (2008). ISSN 1364-503X

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Abstract

It is well known that (i) the flexibility and rigidity of proteins are central to their function, (ii) a number of oligomers with several copies of individual protein chains assemble with symmetry in the native state and (iii) added symmetry sometimes leads to added flexibility in structures. We observe that the most common symmetry classes of protein oligomers are also the symmetry classes that lead to increased flexibility in certain three-dimensional structures—and investigate the possible significance of this coincidence. This builds on the well-developed theory of generic rigidity of body–bar frameworks, which permits an analysis of the rigidity and flexibility of molecular structures such as proteins via fast combinatorial algorithms. In particular, we outline some very simple counting rules and possible algorithmic extensions that allow us to predict continuous symmetry-preserving motions in body–bar frameworks that possess non-trivial point-group symmetry. For simplicity, we focus on dimers, which typically assemble with twofold rotational axes, and often have allosteric function that requires motions to link distant sites on the two protein chains.

Item Type:
Journal Article
Journal or Publication Title:
Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2600
Subjects:
ID Code:
63625
Deposited By:
Deposited On:
22 Apr 2013 11:02
Refereed?:
Yes
Published?:
Published
Last Modified:
26 Aug 2020 01:09