Moody, Catherine L. and Franckevicius, Vilius and Drouhin, Pauline and Klein, Johannes E. M. N. and Taylor, Richard J. K. (2012) Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation. Tetrahedron Letters, 53 (15). pp. 1897-1899. ISSN 0040-4039
Full text not available from this repository.Abstract
A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.