The importance of cellular localisation of probes: synthesis, photophysical properties, DNA interactions and cellular imaging properties of rhenium dppz complexes with known cellular localisation vectors.

Thorp-Greenwood, Flora L. and Coogan, Michael and Mishra, Lallan and Kumari, Niraj and Rai, Geeta and Saripella, Srikrishna (2012) The importance of cellular localisation of probes: synthesis, photophysical properties, DNA interactions and cellular imaging properties of rhenium dppz complexes with known cellular localisation vectors. New Journal of Chemistry, 36 (1). pp. 64-72. ISSN 1369-9261

Full text not available from this repository.

Abstract

The synthesis, photophysical properties, DNA binding, DNA cleavage and cellular imaging behaviour of a range of complexes of the type [Re(CO)3(dppz)(PyR)]+ are reported, where PyR represents a range of substituted pyridines which have previously been studied for cellular localisation of related complexes. Confocal imaging experiments confirm that the complexes retain the variety of cellular localisation behaviour associated with the PyR units in other complexes, and suggest applications as probes for oligonucleotides in specific cellular compartments (e.g. mitochondrial DNA). This study illustrates the importance of considering cellular localisation as a prime consideration in the design of probes for in vivo application.

Item Type:
Journal Article
Journal or Publication Title:
New Journal of Chemistry
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1500/1503
Subjects:
ID Code:
62482
Deposited By:
Deposited On:
22 Feb 2013 13:32
Refereed?:
Yes
Published?:
Published
Last Modified:
13 May 2020 02:03