Gold (I) Complexes Derived From Alkynoxy-substituted Anthraquinones: Syntheses, Luminescence, Cytotoxicity and Cell Imaging Studies,

Balasingham, Rebeca G. and Williams, Catrin F. and Mottram, Huw J. and Coogan, Michael and Pope, Simon J. A. (2012) Gold (I) Complexes Derived From Alkynoxy-substituted Anthraquinones: Syntheses, Luminescence, Cytotoxicity and Cell Imaging Studies,. Organometallics, 31 (16). pp. 5835-5843. ISSN 1520-6041

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Abstract

A series of mono- and dimetallic Au(I) triphenylphosphine complexes derived from 1,2-, 1,4-, and 1,8-dialkynyloxyanthraquinone have been prepared. The photophysical and cytotoxic behavior of the ligands and complexes have been explored, with all of the complexes showing both appreciable cytotoxicity against the MCF-7 carcinoma cell line and useful room-temperature anthraquinone-based visible luminescence, which allowed their successful application as fluorophores in cell imaging microscopy. The implications of the photophysical and toxicological properties for the design and investigation of gold-based anticancer agents are discussed.

Item Type: Journal Article
Journal or Publication Title: Organometallics
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1600/1604
Subjects:
ID Code: 62477
Deposited By: ep_importer_pure
Deposited On: 22 Feb 2013 11:56
Refereed?: Yes
Published?: Published
Last Modified: 11 Feb 2020 08:07
URI: https://eprints.lancs.ac.uk/id/eprint/62477

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