Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD

Hill, VL and Passerini, N and Craig, DQM and Vickers, M and Anwar, J and Feely, LC (1998) Investigation of progesterone loaded poly(D,L-lactide) microspheres using TMDSC, SEM and PXRD. Journal of Thermal Analysis and Calorimetry, 54 (2). pp. 673-685. ISSN 1388-6150

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Abstract

Poly(d,l-lactide) microspheres with progesterone loadings of 0, 10, 20, 30 and 50% w/w were manufactured using an interrupted solvent evaporation process. Spherical microspheres with loadings close to the theoretical values were produced. The glass transition of the polymer could be identified by a step change in the heat capacity measured by TMDSC. Progesterone was found to plasticise the glass transition temperature at contents of 20% w/w or less. At a 30% loading, cold crystallisation of progesterone was seen indicating that an amorphous form of the drug was present; these microspheres were found to exhibit a pitted surface. TMDSC of the 50% progesterone samples suggested that most of the drug was present as crystals. This was supported by the SEM and PXRD results.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Thermal Analysis and Calorimetry
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3100/3104
Subjects:
ID Code:
62226
Deposited By:
Deposited On:
14 Feb 2013 15:11
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Apr 2020 02:22