Peutz-Jeghers syndrome and screening for pancreatic cancer

Latchford, A. and Greenhalf, W. and Vitone, L. J. and Neoptolemos, J. P. and Lancaster, Gillian and Phillips, R. K. S. (2006) Peutz-Jeghers syndrome and screening for pancreatic cancer. British Journal of Surgery, 93 (12). pp. 1446-1455. ISSN 0007-1323

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Background: Cancer risk, including pancreatic, is high in those with Peutz–Jeghers syndrome (PJS). It has been suggested that such patients should undergo screening for pancreatic cancer. Methods: The risk of pancreatic cancer in PJS, pancreatic screening and potential screening strategies were reviewed. Cost-effectiveness was assessed according to American Gastroenterology Association guidelines and a risk stratification model proposed by the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer. Results: The risk of pancreatic cancer is increased in PJS but screening would cost over US $350 000 per life saved. Risk stratification reduces cost by $100 000 and costs fall to $50 000 per life saved if deaths from other forms of cancer are avoided. Conclusion: Screening should be performed only on a research basis to evaluate the benefit and cost-effectiveness in high-risk groups

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Journal Article
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British Journal of Surgery
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12 Nov 2012 11:04
Last Modified:
21 Sep 2023 01:26