Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability

Alhamoruni, A. and Wright, Karen and Larvin, M. and O'Sullivan, S. E. (2012) Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability. British Journal of Pharmacology, 165 (8). pp. 2598-610. ISSN 1476-5381

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Activation of cannabinoid receptors decreases emesis, inflammation, gastric acid secretion and intestinal motility. The ability to modulate intestinal permeability in inflammation may be important in therapy aimed at maintaining epithelial barrier integrity. The aim of the present study was to determine whether cannabinoids modulate the increased permeability associated with inflammation in vitro.

Item Type:
Journal Article
Journal or Publication Title:
British Journal of Pharmacology
Additional Information:
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
Uncontrolled Keywords:
?? intestinal permeabilityinflammationcaco-2 cellscytokinestransepithelial electrical resistance (teer)endocannabinoid cannabinoid cb1 receptor;Δ9-tetrahydrocannabinol and cannabidiolbiomedical and life sciencespharmacologyrm therapeutics. pharmacology ??
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Deposited On:
09 Oct 2012 15:48
Last Modified:
15 Jul 2024 13:19