Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells

Evans, C A and Owen-Lynch, P J and Whetton, A D and Dive, C (1993) Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells. Cancer Research, 53 (8). pp. 1735-1738. ISSN 0008-5472

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Abstract

A chromosomal translocation uniquely associated with chronic myeloid leukemia leads to the formation of a chimeric gene, bcr-abl, on the Philadelphia chromosome. The BRC-ABL protein displays an uncontrolled tyrosine kinase activity similar to that seen with the transforming oncogene of the Abelson murine leukemia (ABL) virus (v-abl). An interleukin 3 dependent cell line, IC.DP, has been transfected with a gene encoding a temperature sensitive v-ABL. In the absence of interleukin 3 at the restrictive temperature for ABL tyrosine kinase activity IC.DP cells died via apoptosis. At the permissive temperature ABL tyrosine kinase activity promoted IC.DP cell survival but not proliferation. ABL therefore can specifically suppress apoptosis.

Item Type:
Journal Article
Journal or Publication Title:
Cancer Research
Uncontrolled Keywords:
/dk/atira/pure/core/keywords/biologicalsciences/biomedicalandlifesciences
Subjects:
?? biomedical and life sciencescancer researchoncologyqr microbiology ??
ID Code:
56090
Deposited By:
Deposited On:
24 Jul 2012 10:51
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Jul 2024 13:01