Nutritional Immunology: A Multi-Dimensional Approach

Ponton, Fleur and Wilson, Kenneth and Cotter, Sheena C. and Raubenheimer, David and Simpson, Stephen J. (2011) Nutritional Immunology: A Multi-Dimensional Approach. PLoS Pathogens, 7 (12). -. ISSN 1553-7374

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Abstract

Nutrition is critical to immune defence and resistance to pathogens, with consequences that affect the health, welfare, and reproductive success of individual organisms [1], [2], and also has profound ecological and evolutionary implications [3]–[5]. In humans, under-nutrition, notably of protein, is a major contributor to morbidity and mortality due to infectious diseases, particularly in the developing world [1]. Likewise, over-nutrition and its associated metabolic disorders may impair immune function, disrupt the relationship with symbiotic and commensal microbiota, and increase susceptibility to infectious disease [6]. Despite the undoubted importance of nutrition to immune defence, the challenge remains to capture the complexity of this relationship. There are three main aspects to this complexity: (i) nutrition is a complex multi-dimensional problem for hosts, pathogens, and commensals; (ii) host immunity is a complex, multi-dimensional trait; and (iii) nutrition and immunity interact via multiple direct and indirect pathways, including involvement of the host's microbiota.

Item Type:
Journal Article
Journal or Publication Title:
PLoS Pathogens
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400/2405
Subjects:
ID Code:
53496
Deposited By:
Deposited On:
13 Apr 2012 11:14
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jul 2020 09:48