An observational prospective study of topical acidified nitrite for killing methicillin-resistant Staphylococcus aureus (MRSA) in contaminated wounds

Ormerod, Anthony D. and Shah, Amjad A. J. and Li, Hong and Benjamin, Nigel and Ferguson, Gail P. and Leifert, Carlo (2011) An observational prospective study of topical acidified nitrite for killing methicillin-resistant Staphylococcus aureus (MRSA) in contaminated wounds. BMC Research Notes, 4. ISSN 1756-0500

[img]
Preview
PDF
1756_0500_4_458.pdf - Published Version
Available under License Creative Commons Attribution.

Download (380kB)

Abstract

Background Endogenous nitric oxide (NO) kills bacteria and other organisms as part of the innate immune response. When nitrite is exposed to low pH, NO is generated and has been used as an NO delivery system to treat skin infections. We demonstrated eradication of MRSA carriage from wounds using a topical formulation of citric acid (4.5%) and sodium nitrite (3%) creams co-applied for 5 days to 15 wounds in an observational prospective pilot study of 8 patients. Findings Following treatment with topical citric acid and sodium nitrite, 9 of 15 wounds (60%) and 3 of 8 patients (37%) were cleared of infection. MRSA isolates from these patients were all sensitive to acidified nitrite in vitro compared to methicillin-sensitive S. aureus and a reference strain of MRSA. Conclusions Nitric oxide and acidified nitrite offer a novel therapy for control of MRSA in wounds. Wounds that were not cleared of infection may have been re-contaminated or the bioavailability of acidified nitrite impaired by local factors in the tissue.

Item Type:
Journal Article
Journal or Publication Title:
BMC Research Notes
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
52393
Deposited By:
Deposited On:
24 Jan 2012 10:32
Refereed?:
Yes
Published?:
Published
Last Modified:
31 Oct 2020 02:18