Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology

Allsop, D and Kidd, M and Landon, M and Tomlinson, A (1986) Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. Journal of Neurology, Neurosurgery and Psychiatry, 49 (8). pp. 886-892. ISSN 0022-3050

Abstract

Frontal and temporal cortical tissue from the brains of elderly cases of Down's syndrome was used to make preparations of neuronal cell bodies containing senile plaque cores. Polarisation microscopy revealed normal "classical" plaque cores, and also a high proportion of unusual "amorphous" plaque cores which we have not seen in Alzheimer's disease. These two forms were easily distinguished by electron microscopy. This suggests that late Down's syndrome may not be an exact model for Alzheimer's disease.