Inflammatory mechanisms in Alzheimer's disease

Eikelenboom, P and Zhan, S S and van Gool, W A and Allsop, D (1994) Inflammatory mechanisms in Alzheimer's disease. Trends in Pharmacological Sciences, 15 (12). pp. 447-450. ISSN 0165-6147

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Alzheimer's disease is aetiologically heterogeneous, but the pathogenesis is often considered to be initiated by the deposition of amyloid fibrils, followed by neuritic tau pathology and neuronal death. A variety of inflammatory proteins has been identified in the brains of patients with Alzheimer's disease post mortem. In this article, Piet Eikelenboom and colleagues review evidence to suggest that the inflammatory processes are intimately involved in several crucial events in the pathological cascade. This suggests possibilities for the treatment of Alzheimer's disease with anti-inflammatory drugs.

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Journal Article
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Trends in Pharmacological Sciences
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07 Nov 2011 16:12
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21 Nov 2022 21:49