Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease

Taylor, Mark and Moore, Susan and Mayes, Jennifer and Parkin, Edward and Beeg, Marten and Canovi, Mara and Gobbi, Marco and Mann, David M A and Allsop, David (2010) Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease. Biochemistry, 49 (15). pp. 3261-3272. ISSN 1520-4995

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Abstract

The formation of beta-amyloid (Abeta) deposits in the brain is likely to be a seminal step in the development of Alzheimer's disease. Recent studies support the hypothesis that Abeta soluble oligomers are toxic to cells and have potent effects on memory and learning. Inhibiting the early stages of Abeta aggregation could, therefore, provide a novel approach to treating the underlying cause of AD. We have designed a retro-inverso peptide (RI-OR2, H(2)N-r

Item Type:
Journal Article
Journal or Publication Title:
Biochemistry
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1303
Subjects:
ID Code:
50812
Deposited By:
Deposited On:
07 Nov 2011 10:13
Refereed?:
Yes
Published?:
Published
Last Modified:
20 Oct 2020 01:49