Taylor, Mark and Moore, Susan and Mayes, Jennifer and Parkin, Edward and Beeg, Marten and Canovi, Mara and Gobbi, Marco and Mann, David M A and Allsop, David (2010) Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease. Biochemistry, 49 (15). pp. 3261-3272. ISSN 1520-4995
Full text not available from this repository.Abstract
The formation of beta-amyloid (Abeta) deposits in the brain is likely to be a seminal step in the development of Alzheimer's disease. Recent studies support the hypothesis that Abeta soluble oligomers are toxic to cells and have potent effects on memory and learning. Inhibiting the early stages of Abeta aggregation could, therefore, provide a novel approach to treating the underlying cause of AD. We have designed a retro-inverso peptide (RI-OR2, H(2)N-r