Measuring health-related quality of life in clinical trials in cystic fibrosis

Abbott, Janice and Hart, Anna and Havermans, T and Matossian, A and Goldbeck, L and Barreto, C and Bergsten-Brucefors, A and Besier, T and Catastini, P and Lupi, F and Staab, D (2011) Measuring health-related quality of life in clinical trials in cystic fibrosis. Journal of Cystic Fibrosis, 10 (Supple). S82-S85.

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Abstract

The inclusion of health-related quality of life (HRQoL) as an outcome measure in cystic fibrosis (CF) clinical trials can supply important patient-reported information not captured by other endpoints. Both an appropriate HRQoL measure and sound methodology are required in order to draw valid inferences about treatments and HRQoL. This paper provides the current consensus of the HRQoL Outcomes Group. Particular consideration has been given to the appropriateness of measurement scales, the rationale for including specific domains as endpoints, the importance of considering baseline ceiling effects and the difficulties of data interpretation. Guidance is provided on HRQoL measurement in National and European CF clinical trials.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Cystic Fibrosis
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2740
Subjects:
ID Code:
50713
Deposited By:
Deposited On:
03 Nov 2011 11:48
Refereed?:
Yes
Published?:
Published
Last Modified:
07 Jan 2020 03:30