Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

Clancy, D. J. and Gems, D. and Harshman, L. G. and Oldham, S. and Stocker, H. and Hafen, E. and Leevers, S. J. and Partridge, L. (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science, 292 (5514). pp. 104-106.

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Abstract

The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. in the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median Life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of Life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of Life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

Item Type:
Journal Article
Journal or Publication Title:
Science
Additional Information:
Apr 6 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1000
Subjects:
ID Code:
50161
Deposited By:
Deposited On:
30 Sep 2011 15:49
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Oct 2020 08:27