Identifying common determinants of lifespan and ageing in model organisms

Clancy, D. J. and Keaney, M. and Leevers, S. J. and Partridge, L. and Gems, D. (2002) Identifying common determinants of lifespan and ageing in model organisms. Mechanisms of Development, 123 (4). pp. 441-442.

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Genetic and environmental manipulations have revealed a number of determinants of lifespan in model organisms. For example, in the nematode Caenorhabditis elegans, an insulin/IGF signalling (IIS) pathway regulates the rate of ageing (Guarente and Kenyon, 2000), while in the fruitfly Drosophila melanogaster, lifespan is inversely proportional to reproductive effort (Partridge and Barton, 1993). Calorie restriction (CR) increases lifespan in many species and lifespan increases induced by various means is accompanied by increased stress resistance. But, how many of these findings reflect general features of lifespan determination rather than idiosyncrasies of particular model organisms? And how are IIS, CR, reproductive effort and stress resistance related to each other in their effects on longevity? To investigate these issues, we have compared lifespan determinants in C. elegans and Drosophila. We have evidence that in Drosophila, as in C. elegans, IIS regulates lifespan (Clancy et al., 2001), suggesting an evolutionarily conserved role for IIS in lifespan determination (Gems and Partridge, 2001). We are also examining interactions between CR and IIS, and the results are consistent with a role for IIS in the effect of CR on the lifespan in Drosophila. However, previous reports have suggested that in C.elegans, the effects of CR and IIS on lifespan involve different mechanisms (Lakowski and Hekimi, 1998; Vanfleteren and Braeckman, 1999).

Item Type:
Journal Article
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Mechanisms of Development
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Feb Identifying common determinants of lifespan and ageing in model organisms
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30 Sep 2011 15:33
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18 Sep 2023 00:27