DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

Broughton, Susan J and Slack, Cathy and Alic, Nazif and Metaxakis, Athanasios and Bass, Timothy M and Driege, Yasmine and Partridge, Linda (2010) DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. Aging Cell, 9 (3). pp. 336-46. ISSN 1474-9726

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Abstract

Dietary restriction extends lifespan in diverse organisms, but the gene regulatory mechanisms and tissues mediating the increased survival are still unclear. Studies in worms and flies have revealed a number of candidate mechanisms, including the target of rapamycin and insulin/IGF-like signalling (IIS) pathways and suggested a specific role for the nervous system in mediating the response. A pair of sensory neurons in Caenorhabditis elegans has been found to specifically mediate DR lifespan extension, but a neuronal focus in the Drosophila nervous system has not yet been identified. We have previously shown that reducing IIS via the partial ablation of median neurosecretory cells in the Drosophila adult brain, which produce three of the seven fly insulin-like peptides, extends lifespan. Here, we show that these cells are required to mediate the response of lifespan to full feeding in a yeast dilution DR regime and that they appear to do so by mechanisms that involve both altered IIS and other endocrine effects. We also present evidence of an interaction between these mNSCs, nutrition and sleep, further emphasising the functional homology between the DILP-producing neurosecretory cells in the Drosophila brain and the hypothalamus of mammals in their roles as integration sites of many inputs for the control of lifespan and behaviour.

Item Type:
Journal Article
Journal or Publication Title:
Aging Cell
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1302
Subjects:
ID Code:
49882
Deposited By:
Deposited On:
20 Sep 2011 09:20
Refereed?:
Yes
Published?:
Published
Last Modified:
08 Jul 2020 02:55