THE UPTAKE OF IGG BY HUMAN PLACENTAL CHORIONIC VILLI:A CORRELATED AUTORADIOGRAPHIC AND WIDE APERTURE COUNTING STUDY

OCKLEFORD, C D and CLINT, J M (1980) THE UPTAKE OF IGG BY HUMAN PLACENTAL CHORIONIC VILLI:A CORRELATED AUTORADIOGRAPHIC AND WIDE APERTURE COUNTING STUDY. Placenta, 1 (2). pp. 91-111. ISSN 0143-4004

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Abstract

The uptake of 3H-IgG into human placental chorionic villi in vitro takes place for at least 1 h at 37°C and at 4°C. The rate of uptake is lower at the latter temperature, but still about 20 per cent of the 37°C total. Measurement of cell-associated radioactivity at 4°C cannot therefore be used as a measure of binding: genuine uptake, probably as a result of endocytosis, appears to occur at this temperature. Some proportion of the uptake of IgG at 37°C can be inhibited by colchicine and by cytochalasin B, but some is refractory to these treatments. A coated vesicle-enriched fraction isolated from placenta previously incubated with 3H-IgG was found to be associated with radioisotope.

Item Type:
Journal Article
Journal or Publication Title:
Placenta
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2743
Subjects:
ID Code:
49312
Deposited By:
Deposited On:
29 Jul 2011 13:41
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 07:35