Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues

Rogers, Matthew Edward and Corware, Karina and Müller, Ingrid and Bates, Paul Andrew (2010) Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues. Microbes and Infection, 12 (11). pp. 875-879. ISSN 1769-714X

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Abstract

We demonstrate that a proteophosphoglycan-rich gel secreted by Leishmania infantum inside the midgut of Lutzomyia longipalpis sand flies (promastigote secretory gel) is regurgitated along with an average dose of 500 L. infantum metacyclic promastigotes per infected bite. Using both low (10³) and high (10⁵) doses of parasites in the ears of BALB/c mice we show that the infections benefit from the presence of vector saliva and parasite gel in the skin. However, chronic infection of the spleen was only enhanced in high dose co-infections with gel. These results provide the framework for a more natural experimental model of visceral leishmaniasis.

Item Type:
Journal Article
Journal or Publication Title:
Microbes and Infection
Additional Information:
Copyright © 2010. Published by Elsevier SAS.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400/2404
Subjects:
ID Code:
49222
Deposited By:
Deposited On:
27 Jul 2011 13:51
Refereed?:
Yes
Published?:
Published
Last Modified:
06 May 2020 02:06