The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids

Rudd, Timothy R. and Skidmore, Mark A. and Guimond, Scott E. and Holman, Joseph and Turnbull, Jeremy E. and Lauder, Robert M. and Fernig, David G. and Yates, Edwin A. (2009) The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. Thrombosis and Haemostasis, 102 (5). pp. 874-878. ISSN 0340-6245

[img]
Preview
PDF
Rudd_et_al_2009_Thromb_Haemost_102_874_878.pdf - Published Version

Download (169kB)

Abstract

The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.

Item Type:
Journal Article
Journal or Publication Title:
Thrombosis and Haemostasis
Uncontrolled Keywords:
/dk/atira/pure/researchoutput/libraryofcongress/r1
Subjects:
ID Code:
34800
Deposited By:
Deposited On:
08 Dec 2010 14:55
Refereed?:
Yes
Published?:
Published
Last Modified:
15 Aug 2020 01:32