Elimination kinetic model for organic chemicals in earthworms.

Dimitrova, N. and Dimitrov, S. and Georgieva, Denitsa and Van Gestel, C. A. M. and Hankard, P. and Spurgeon, D. and Li, Hong and Mekenyan, O. (2010) Elimination kinetic model for organic chemicals in earthworms. Science of the Total Environment, 408 (18). pp. 3787-3793. ISSN 0048-9697

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Mechanistic understanding of bioaccumulation in different organisms and environments should take into account the influence of organism and chemical depending factors on the uptake and elimination kinetics of chemicals. Lipophilicity, metabolism, sorption (bioavailability) and biodegradation of chemicals are among the important factors that may significantly affect the bioaccumulation process in soil organisms. This study attempts to model elimination kinetics of organic chemicals in earthworms by accounting for the effects of both chemical and biological properties, including metabolism. The modeling approach that has been developed is based on the concept for simulating metabolism used in the BCF base-line model developed for predicting bioaccumulation in fish. Metabolism was explicitly accounted for by making use of the TIMES engine for simulation of metabolism and a set of principal transformations. Kinetic characteristics of transformations were estimated on the basis of observed kinetics data for the elimination of organic chemicals from earthworms.

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Journal Article
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Science of the Total Environment
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Deposited On:
27 Jan 2010 16:28
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21 Nov 2022 19:43