Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.

Clark, J. and Merson, S. and Jhavar, S. and Flohr, P. and Edwards, S. and Foster, C. S. and Eeles, R. and Martin, Frank L. and Phillips, D. H. and Crundwell, M. and Christmas, T. and Thompson, A. and Fisher, C. and Kovacs, G. and Cooper, C. S. (2007) Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. Oncogene, 26 (18). pp. 2667-2673. ISSN 0950-9232

Full text not available from this repository.


TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.

Item Type:
Journal Article
Journal or Publication Title:
Uncontrolled Keywords:
ID Code:
Deposited By:
Deposited On:
14 Jan 2010 10:59
Last Modified:
21 Nov 2022 19:41