Charge fluctuations and boundary conditions of biological ion channels:effect on the ionic transition rate

Tindjong, R. and Luchinsky, D. G. and McClintock, P. V. E. and Eisenberg, R. S. (2009) Charge fluctuations and boundary conditions of biological ion channels:effect on the ionic transition rate. AIP Conference Proceedings, 1129. pp. 535-538. ISSN 0094-243X

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Abstract

A self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge fluctuations at the mouth are modeled as shot noise flipping the height of the potential barrier at the selectivity site. The resultant estimates of the conductivity of the ion channel are in good agreement with Gramicidin experimental measurements and they reproduce the observed current saturation with increasing concentration.

Item Type:
Journal Article
Journal or Publication Title:
AIP Conference Proceedings
Additional Information:
Copyright 2009 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in AIP Conference Proceedings, 1129 (535), 2009 and may be found at http://link.aip.org/link/?APCPCS/1129/535/1
Uncontrolled Keywords:
/dk/atira/pure/researchoutput/libraryofcongress/qc
Subjects:
ID Code:
31245
Deposited On:
06 Jan 2010 14:30
Refereed?:
No
Published?:
Published
Last Modified:
16 Jul 2020 04:02