Intrinsic dynamics of heart regulatory systems on short timescales: from experiment to modelling.

Khovanov, I. A. and Khovanova, N. A. and McClintock, P. V. E. and Stefanovska, A. (2009) Intrinsic dynamics of heart regulatory systems on short timescales: from experiment to modelling. Journal of Statistical Mechanics: Theory and Experiment, P01016.

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Abstract

We discuss open problems related to the stochastic modelling of cardiac function. The work is based on an experimental investigation of the dynamics of heart rate variability (HRV) in the absence of respiratory perturbations. We consider first the cardiac control system on short timescales via an analysis of HRV within the framework of a random walk approach. Our experiments show that HRV on timescales of less than a minute takes the form of free diffusion, close to Brownian motion, which can be described as a nonstationary process with stationary increments. Secondly, we consider the inverse problem of modelling the state of the control system so as to reproduce the experimentally observed HRV statistics of. We discuss some simple toy models and identify open problems for the modelling of heart dynamics.

Item Type: Journal Article
Journal or Publication Title: Journal of Statistical Mechanics: Theory and Experiment
Uncontrolled Keywords: /dk/atira/pure/researchoutput/libraryofcongress/qc
Subjects:
Departments: Faculty of Science and Technology > Physics
ID Code: 31236
Deposited By: Professor P. V. E. McClintock
Deposited On: 07 Jan 2010 09:42
Refereed?: Yes
Published?: Published
Last Modified: 20 Sep 2019 23:58
URI: https://eprints.lancs.ac.uk/id/eprint/31236

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