The action of a mast cell protease on the cuticular collagens of Necator americanus.

McKean, Paul G. and Pritchard, D. I. (1989) The action of a mast cell protease on the cuticular collagens of Necator americanus. Parasite Immunology, 11 (3). pp. 293-297. ISSN 1365-3024

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Abstract

Collagen-like proteins, thought to be responsible for maintaining the structural integrity of the nematode cuticle, were isolated from adult Necator americanus and shown to be susceptible to digestion by purified mast cell proteases. Although these collagens would appear normally to be masked by superficially expressed (surface) antigens, it is suggested that a sufficiently avid and specific immune response could remove this potentially protective coat, rendering the structurally important underlying layers open to immune attack.

Item Type:
Journal Article
Journal or Publication Title:
Parasite Immunology
Uncontrolled Keywords:
/dk/atira/pure/researchoutput/libraryofcongress/qh301
Subjects:
?? IMMUNOLOGYPARASITOLOGYQH301 BIOLOGY ??
ID Code:
26067
Deposited By:
Deposited On:
09 Mar 2009 16:34
Refereed?:
Yes
Published?:
Published
Last Modified:
17 Sep 2023 00:30