Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro.

O’Dea, Kieran P. and McKean, Paul G. and Harris, Alan and Brown, K. Neil (1995) Processing of the Plasmodium chabaudi chabaudi AS merozite surface protein 1 in vivo and in vitro. Molecular and Biochemical Parasitology, 72 (1-2). pp. 111-119. ISSN 0166-6851

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Abstract

Processing of the Plasmodium merozoite surface protein 1 (MSP-1) has been described for parasites maintained under in vitro conditions. We have now demonstrated, using CBA/Ca mice infected with Plasmodium chabaudi chabaudi AS, that MSP-1 processing also occurs in vivo. The major proteolytic cleavage sites and a processing scheme were deduced from N-terminal amino-acid sequences of the MSP-1 breakdown products. Comparison of MSP-1 processing in P. falciparum and P.c. chabaudi indicates a degree of conservation and in two cases the position of protease cleavage appears identical. Significant amounts of MSP-1 polypeptides are found in plasma during schizogony. Various aspects of MSP-1 processing including immunological and physiological reactions in the host during the critical period of schizogony can now be examined in vivo.

Item Type:
Journal Article
Journal or Publication Title:
Molecular and Biochemical Parasitology
Uncontrolled Keywords:
/dk/atira/pure/researchoutput/libraryofcongress/qh301
Subjects:
ID Code:
26053
Deposited By:
Deposited On:
12 Mar 2009 09:55
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 06:39