Exploratory analysis of longitudinal trials with staggered intervention times.

Chetwynd, Amanda G. and Diggle, Peter J. and Sousa, Ines (2005) Exploratory analysis of longitudinal trials with staggered intervention times. Biostatistics, 6 (3). pp. 479-485. ISSN 1468-4357

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Abstract

Longitudinal trials involving surgical interventions commonly have subject-specific intervention times, due to constraints on the availability of surgeons and operating theatres. Moreover, the intervention often effects a discontinuous change in the mean response. We propose a nonparametric estimator for the mean response profile of longitudinal data with staggered intervention times and a discontinuity at the times of intervention, as an exploratory tool to assist the formulation of a suitable parametric model. We use an adaptation of the standard generalized additive model algorithm for estimation, with smoothing constants chosen by a cross-validation criterion. We illustrate the method using longitudinal data from a trial to assess the effect of lung resection surgery in the treatment of emphysema patients.

Item Type:
Journal Article
Journal or Publication Title:
Biostatistics
Additional Information:
RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2600/2613
Subjects:
?? back-fitting algorithmcross-validationexploratory analysislongitudinal trialslung resection surgerynonparametric estimatorstatistics and probabilitystatistics, probability and uncertaintygeneral medicinemedicine(all)qa mathematics ??
ID Code:
2408
Deposited By:
Deposited On:
31 Mar 2008 15:35
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Jul 2024 08:27