Exploratory analysis of longitudinal trials with staggered intervention times.

Chetwynd, Amanda G. and Diggle, Peter J. and Sousa, Ines (2005) Exploratory analysis of longitudinal trials with staggered intervention times. Biostatistics, 6 (3). pp. 479-485. ISSN 1468-4357

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Longitudinal trials involving surgical interventions commonly have subject-specific intervention times, due to constraints on the availability of surgeons and operating theatres. Moreover, the intervention often effects a discontinuous change in the mean response. We propose a nonparametric estimator for the mean response profile of longitudinal data with staggered intervention times and a discontinuity at the times of intervention, as an exploratory tool to assist the formulation of a suitable parametric model. We use an adaptation of the standard generalized additive model algorithm for estimation, with smoothing constants chosen by a cross-validation criterion. We illustrate the method using longitudinal data from a trial to assess the effect of lung resection surgery in the treatment of emphysema patients.

Item Type: Journal Article
Journal or Publication Title: Biostatistics
Additional Information: RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research
Uncontrolled Keywords: /dk/atira/pure/researchoutput/libraryofcongress/qa
Departments: Faculty of Science and Technology > Mathematics and Statistics
VC's Office
Faculty of Health and Medicine > Medicine
Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 2408
Deposited By: ep_importer
Deposited On: 31 Mar 2008 15:35
Refereed?: Yes
Published?: Published
Last Modified: 30 Sep 2019 14:45
URI: https://eprints.lancs.ac.uk/id/eprint/2408

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