Stimuli responsive biomaterials for controlled/triggered/sustained delivery of drugs or biologics

Hardy, John and Cheneler, David and Copeland, Nikki and Mort, Richard (2022) Stimuli responsive biomaterials for controlled/triggered/sustained delivery of drugs or biologics. In: Controlled Release Society 2022 Annual Meeting, 2022-07-11 - 2022-07-15, Le Palais des congrès de Montréal.

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Abstract

Introduction: Stimuli-responsive materials (SRMs) have significant potential for the development of systems capable of the controlled, triggered or sustained delivery of drugs or biologics. Our interest is in the design, synthesis, and characterization of a range of materials capable of responding to one or more stimuli [1-6], particularly when sensors are integrated in such devices [7,8]. Methods: An interdisciplinary approach combining chemistry (polymer synthesis) and materials science and engineering was employed to prepare and characterize SRMs via electrochemistry, microscopy and spectroscopy. SRMs loaded with drugs or biologics were exposed to stimuli, and the release of the drugs or biologics was quantified spectroscopically. Results: Electricity, light and magnetism are capable of triggering the delivery of drugs or biologics of various molecular weights from these SRMs in-vitro. Conclusion/Implications: SRMs can deliver a variety of clinically relevant drugs or biologics of various molecular weights in a controlled, triggered or sustained fashion over extended periods, and can potentially be used to control the chronopharmacology of the drugs or biologics in line with the chronobiology of the condition needing treatment. Acknowledgements: For financial support we thank United Kingdom Research and Innovation (UKRI, specifically BBSRC, EPSRC and MRC), the UK Royal Society, and the British Council Newton-Mosharafa Fund. References: 1) Pharmaceutics2020, 12, 8, 742. 2) Polymer International, 2020. DOI: 10.1002/pi.6089. 3) Macromolecular Materials and Engineering, 2020, 305, 6, 2000130. 4) ACS Omega, 2020, 5, 3, 1549-1556. 5) Analyst, 2021, 146, 9, 2784-2806.