Sharma, Manoj and Cheneler, David and Hardy, John (2023) Towards stimuli-responsive polymer-based hydrogels integrated in smart drug delivery devices. In: Controlled Release Society 2023 Annual Meeting & Expo, 2023-07-24 - 2023-07-28, Paris Hotel.
Full text not available from this repository.Abstract
Introduction: Controlled release of drugs upon the application of a stimulus to trigger release provides the opportunity to deliver precise quantities of drugs to target tissues, potentially providing treatments that are tailored to the specific condition/patient. Here we integrate stimuli-responsive microneedles in delivery systems.1-3 Methods: Polymer hydrogel-based microneedles were prepared, rendered stimuli-responsive, and characterised (mechanics [compressive/shear], microscopy [e.g., confocal, optical, SEM], spectroscopy [e.g., EDX, FTIR], swelling, etc.). Hydrogels were integrated into devices capable of sensing/responding to signals (e.g., electricity/light), followed by in vitro validation of drug loading/release. Results: “Smart” microneedle-based drug delivery systems were successfully prepared and characterized by a variety of techniques, with demonstration of the use of stimuli (e.g., electricity/light) to control delivery of therapeutics in vitro. Conclusion: Such systems potentially enable on-demand triggerable drug release over an extended period, alleviating the need for multiple injections, and/or facilitating their integration in implantable devices. Acknowledgements: For financial support we thank the Indian Ministry of Social Justice & Empowerment (Government of India) and High Commission of India in London (grant reference: 11015/75/2017-SCD-V), and the British Council UK (grant reference: 336872) and Royal Society for support of J.G.H. (grant reference: RG160449). References: 1. J. G. Hardy, E. Larrañeta, R. F. Donnelly, N. McGoldrick, K. Migalska, M. T. C. McCrudden, N. J. Irwin, L. Donnelly, C. P. McCoy. Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery. Mol. Pharm., 2016, 13, 3, 907-914. 2. Sharma MB, D. Cheneler, et al., Submitted. 3. Sharma MB, D. Cheneler, et al., In preparation.