Mota, T.F. and Fukutani, E.R. and Martins, K.A. and Salgado, V.R. and Andrade, B.B. and Fraga, D.B.M. and Queiroz, A.T.L. (2023) Another tick bites the dust : exploring the association of microbial composition with a broad transmission competence of tick vector species. Microbiology Spectrum, 11 (6): e02156-23.
Full text not available from this repository.Abstract
Ticks harbor and transmit many different pathogens. While some species are competent vectors of a single pathogen, mono-competent vectors (MCV), other species are proven to be competent vectors of several pathogens, pluri-competent vectors (PCV). Such a difference in vector competence might be related to the microbiome. To better comprehend its influence on the vector competence of ticks for one or several pathogens, a data-driven approach using publicly available databases was applied on bacterial 16S rRNA from MCV and PCV tick species. Alpha and beta diversity, co-occurrence networks, and functional profiles were analyzed. A differential analysis was performed to identify bacterial genera associated with PCV ticks. These tick species presented higher richness, and the bacterial composition showed a significant difference between MCV and PCV ticks. The bacteria genera of PCV ticks demonstrated fewer correlations within each other in comparison with MCV ticks. The differential analysis revealed 14 bacteria genera related to PCV tick species, such as Rickettsia, Staphylococcus, and Corynebacterium. Using 24 differently abundant genera, tick samples from another data set could be classified into either PCV or MCV with high accuracy and concordance. Moreover, pathway regulation related to reactive oxygen species detoxification, β-Lactam resistance, and dTDP-L-rhamnose biosynthesis could be participating in the competence of PCV ticks for several tick-borne pathogens. These findings enlighten our understanding of the bacteria community’s role on some tick species’ broad vector competence.